Insiders and Outsiders: The Case for Alaska Reclaiming Its Cultural Property

Because of the historically troubling treatment of American Indians by the United States government, the nation’s native populations have been largely unable to control their cultural identities. Cultural property laws provide a framework for transferring stolen art and cultural objects to their native owners in an attempt to return cultural sovereignty to native communities. Despite Alaska’s large and thriving native population, Alaska Natives have trailed behind other states’ native populations in asserting their cultural property rights. This Note considers the current cultural property framework and its evolution in an effort to understand why Alaska Natives are not seeking return of their cultural objects to the same extent as other native groups

Endocrine therapy resistant ESR1 variants revealed by genomic characterization of breast cancer derived xenografts

To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained with high fidelity. However, at the single-nucleotide level, variable numbers of PDX-specific somatic events were documented, although they were only rarely functionally significant. Variant allele frequencies were often preserved in the PDXs, demonstrating that clonal representation can be transplantable. Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation. These events produced different endocrine-therapy-response phenotypes in human, cell line, and PDX endocrine-response studies. Hence, deeply sequenced PDX models are an important resource for the search for genome-forward treatment options and capture endocrine-drug-resistance etiologies that are not observed in standard cell lines. The originating tumor genome provides a benchmark for assessing genetic drift and clonal representation after transplantation

Data from: Affinity for natal environments by dispersers impacts reproduction and explains geographic structure of a highly mobile bird

Understanding dispersal and habitat selection behaviours is central to many problems in ecology, evolution and conservation. One factor often hypothesized to influence habitat selection by dispersers is the natal environment experienced by juveniles. Nonetheless, evidence for the effect of natal environment on dispersing, wild vertebrates remains limited. Using 18 years of nesting and mark–resight data across an entire North American geographical range of an endangered bird, the snail kite (Rostrhamus sociabilis), we tested for natal effects on breeding-site selection by dispersers and its consequences for reproductive success and population structure. Dispersing snail kites were more likely to nest in wetlands of the same habitat type (lacustrine or palustrine) as their natal wetland, independent of dispersal distance, but this preference declined with age and if individuals were born during droughts. Importantly, dispersing kites that bred in natal-like habitats had lower nest success and productivity than kites that did not. These behaviours help explain recently described population connectivity and spatial structure across their geographical range and reveal that assortative breeding is occurring, where birds are more likely to breed with individuals born in the same wetland type as their natal habitat. Natal environments can thus have long-term and large-scale effects on populations in nature, even in highly mobile animals

conditional_logit_data for Dryad_FINAL

conditional_logit_data for Dryad_FINA

nests_success_data for Dryad

data to compare nest success between individuals who nest in habitat types similar to natal habitat type versus those that don'

nest_fledge_data for Dryad_FINAL

maladaptive habitat selection and explains geographic structure of a highly mobile bir

modularity_data for Dryad_FINAL

data to assess drivers of modularit

Aging in a confined place: an exploration of elder inmate health and healthcare

This qualitative case study investigates and analyzes the health and healthcare experience of elderly offenders. Four substantive areas which were examined included: 1) To explore how changes in an inmate's personal health and functional status influenced the healthcare process, 2) To explore how family relationship awareness and involvement affected prisoner health and healthcare, 3) To explore the influence of policy on prisoner health and healthcare and, 4) To explore the influence of the larger societal discourse on prisoner health and healthcare. The study was conducted within three theoretical frameworks: standpoint theory, Cantor's (2000) model of social care of the elderly, and the social construction of the aging inmate. Face-to-face and phone interviews were conducted with sixteen participants. Four of the participants were elder inmates between the ages of 50 and 90 years of age, and had served time in the state of Alabama's only correctional facility designed for the aged and infirm male prisoner. The additional twelve collateral participants were correctional staff, medical personnel, family members, and church and community volunteers. This research contributes to the literature on elderly offenders, and the understanding of experiencing health changes and healthcare in a correctional institution. The study concludes with several recommendations intended to better prepare prisons, healthcare providers and communities for the growing elderly inmate population. (Published By University of Alabama Libraries